THE REPETITIVE OLIGOPEPTIDE SEQUENCES MODULATE CYTOPATHIC POTENCY BUT ARE NOT CRUCIAL FOR CELLULAR UPTAKE OF CLOSTRIDIUM DIFFICILE TOXIN A.

The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A.

The pathogenicity of Clostridium difficile is primarily linked to secretion of the intracellular acting toxins A (TcdA) and B (TcdB) which monoglucosylate and thereby inactivate Rho GTPases of host cells.Although the molecular mode of action of TcdA and TcdB is well understood, far less is known about toxin binding and uptake.It is acknowledged tha

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Prevalence of inappropriateness of elemene injection for hospitalized cancer patients: a multicenter retrospective study

Background: Elemene injection could provide clinical benefit for the treatment of various cancers, but the clinical evidence is weak.Thus, its wide use in China has raised concerns about the appropriateness of its use.Methods: This was a multicenter retrospective study to evaluate the prevalence of inappropriateness of elemene injection for hospita

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